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本组以胎肝移植治疗6例白血病,其中急性白血病5例,慢性粒细胞白血病急变期1例。预处理方案包括环磷酰胺40～50mg/kg,连续静滴2天,~(60)钴分次全身照射5～6Gy,全淋巴结照射6～8Gy。胎肝选择16～24周孕妇,经水囊引产,所得胎肝细胞范围为2.05～11.3×10~9,细胞活力为79～97％。预处理后所有患者骨髓象均处于严重抑制,5例于移植后约24～49天才恢复增生,骨髓处于完全缓解。1例慢性粒细胞白血病死于预处理后严重霉菌感染。2例急性白血病分别于移植后120天及485天死亡。3例急性白血病已分别存活814~+、659~+、485天。
This group of fetal liver transplantation for the treatment of 6 cases of leukemia, including 5 cases of acute leukemia, chronic myeloid leukemia in 1 case of blast crisis. Pretreatment regimens include cyclophosphamide 40 ~ 50mg / kg, continuous intravenous infusion of 2 days, ~ (60) cobalt fractionated whole body irradiation 5 ~ 6Gy, all lymph node irradiation 6 ~ 8Gy. Fetal liver selection for 16 to 24 weeks pregnant women, induced by the water bag, fetal liver cells obtained in the range of 2.05 ~ 11.3 × 10 ~ 9, cell viability of 79 ~ 97%. Bone marrow was severely inhibited in all patients after preconditioning, 5 cases recovered hyperplasia about 24-49 days after transplantation, and bone marrow was completely relieved. One case of chronic myeloid leukemia died of severe mold infection after pretreatment. Two cases of acute leukemia died after 120 days and 485 days after transplantation, respectively. 3 cases of acute leukemia have survived 814 ~ +, 659 ~ +, 485 days.