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目的:探讨和胃理气方对功能性消化不良肝郁模型大鼠胃排空和小肠推进的影响。方法:通过运用郭氏夹尾刺激法制备FD肝郁动物模型,用和胃理气方作为治疗药物,吗丁啉作为对照药物,采用定量方法观察和胃理气方对FD肝郁模型大鼠胃排空和小肠推进的影响,并与吗丁啉组进行比较。结果:和胃理气方能显著改善肝郁模型大鼠的情志和行为的改变,使其自发活动增加,饮水量及摄食量增多,被毛恢复光泽,明显加快胃排空和小肠推进,使胃肠道蠕动增加,与吗丁啉作用相似,且促胃动力作用随着剂量的增加而增强。结论:和胃理气方能增强胃肠道蠕动使肝气得疏,脾胃运化功能恢复正常。
Objective: To investigate the effect of Hewei Liqi Recipe on gastric emptying and small intestine advancing in rats with functional dyspepsia and liver depression. METHODS: The animal model of FD liver qi was prepared by using Guo’s tail-tail stimulation method. Hewei ding-bi was used as a therapeutic drug and domperidone was used as a comparison drug. Quantitative method was used to observe the effect of Hewei Liqi Decoction on gastric row of rats with FD liver-depression. Effects of emptiness and small intestine advancing and compared with domperidone group. RESULTS: Hewei Liqi could significantly improve the mood and behavior of rats with liver-qi stagnation, increase their spontaneous activities, increase their drinking water and food intake, and restore their luster to the coat, significantly accelerating gastric emptying and small intestine advancing. Increased intestinal motility was similar to that of domperidone, and gastric motility increased with increasing dose. Conclusion: Hewei Liqi can enhance the gastrointestinal motility, make liver qi sparse, and spleen and stomach transport function return to normal.