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以甲酸为溶剂,将丝素(SF)和壳聚糖(CS)在不同共混比例下进行静电纺丝。虽然纯CS不能通过静电纺丝成纤维结构,但CS含量为30%的SF/CS共混物可以静电纺成纤维结构。与纯SF纳米纤维相比,SF/CS共混纳米初生纤维直径更小,直径分布范围也变窄。随着共混物中CS含量的增加,纤维直径逐渐从450 nm下降到130 nm。然而,当共混物中CS含量超过40 wt%时,SF纳米纤维中就会含有CS珠状结构。利用ATR红外光谱和固态CP-MAS13C-核磁共振仪研究了甲醇处理对初生SF纤维或SF/CS共混纳米纤维次级结构的影响。与纯的SF纳米纤维相比,SF/CS共混纳米纤维β化速度更快。这是因为刚性骨架的CS通过分子间作用加速了SF的构象转变。
Formic acid was used as a solvent to electrospinning silk fibroin (SF) and chitosan (CS) under different blend ratios. Although pure CS can not be electrospun into a fibrous structure, SF / CS blends with a CS content of 30% can be electrospun into a fibrous structure. Compared with pure SF nanofibers, SF / CS nanofibers have smaller diameter and narrower diameter distribution. As the CS content in the blend increased, the fiber diameter gradually decreased from 450 nm to 130 nm. However, when the CS content in the blend exceeds 40 wt%, the CS nanostructures will be contained in the SF nanofibers. The effect of methanol treatment on the secondary structure of primary SF fibers or SF / CS blend nanofibers was investigated by ATR infrared spectroscopy and solid-state CP-MAS13C-NMR. Compared with pure SF nanofibers, SF / CS nanofibers could be beta-converted faster. This is because the rigid backbone of CS accelerates the conformational transition of SF through intermolecular interactions.