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目的探讨复方瘤痛克的作用机理,为临床用药提供理论依据。方法分别取小鼠48只、44只,大白兔40只,用随机法分组,每组10～12只。阴性对照组给予生理盐水;阳性对照组给予消炎痛、丹参片;中药大小剂量组分别给予复方瘤痛克,用灌胃法给予不同剂量的药物。将二甲苯涂于各组小鼠右耳。诱发小鼠炎性反应;每只小鼠尾静脉注射垂体后叶素,使小动脉血流速度减慢;大白兔耳静脉注射10%高分子右旋糖酐,造成“血瘀”模型。结果复方瘤痛克对二甲苯致炎的小鼠耳肿胀具有显著的抑制作用:同时,该药能明显加快小鼠耳部小动脉的血流速度;对高分子右旋糖酐所致的血瘀模型,具有显著的抑制功效。结论复方瘤痛克具有良好的抗炎消肿、活血化瘀作用。
Objective To explore the mechanism of compound Tutongke and provide theoretical basis for clinical medication. Methods Forty-eight mice and 44 rabbits were used, and 40 rabbits were randomly divided into groups of 10 to 12 in each group. The negative control group was given physiological saline; the positive control group was given indomethacin and Danshen tablets; the Chinese medicine large-dose group was given compound tumor pain grams, and different doses of drugs were given by intragastric administration. Xylene was applied to the right ear of each group of mice. The inflammatory reaction was induced in mice; pituitary vasopressin was injected into the tail vein of each mouse to decrease the blood flow velocity of the small arteries; the white rabbits were injected with 10% polymer dextran to produce a “blood bleed” model. Results Tuanytongke had a significant inhibitory effect on the swelling of ears caused by xylene-induced inflammation: at the same time, the drug could significantly accelerate the blood flow velocity of the mouse ear arterioles; the blood stasis model caused by polymer dextran, Has a significant inhibitory effect. Conclusion Compound Tutongke has good anti-inflammatory, swelling, and blood circulation.