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目的研究肠道去污剂对肝硬化患者肠道屏障功能、内毒素水平及肝功能的影响,为临床治疗提供参考。方法 88例肝硬化患者,随机分为观察组和对照组,各44例,观察组患者采取肠道去污剂治疗,对照组患者采取常规治疗,比较两组患者内毒素水平以及肝功能变化情况。结果观察组患者内毒素水平、肝功能评分以及尿液L/M均明显低于对照组(P<0.05),观察组患者并发症发生率(4.5%)明显低于对照组(29.5%)(P<0.05)。结论肝硬化患者采取肠道去污剂治疗能够明显增强患者的肠道屏障功能,改善肝功能,降低内毒素水平。
Objective To study the effect of intestinal detergent on intestinal barrier function, endotoxin level and liver function in cirrhotic patients and provide reference for clinical treatment. Methods 88 patients with cirrhosis were randomly divided into observation group and control group, 44 cases in each group. Patients in observation group were treated with intestinal detergent, while those in control group were treated routinely. The endotoxin level and changes of liver function in both groups were compared . Results The endotoxin level, liver function score and urine L / M in the observation group were significantly lower than those in the control group (P <0.05). The incidence of complications in the observation group (4.5%) was significantly lower than that in the control group (29.5%) P <0.05). Conclusion The treatment of patients with liver cirrhosis with intestinal detergent can significantly improve the patient’s intestinal barrier function, improve liver function and reduce endotoxin levels.