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目的:探讨50岁以下前列腺癌(PCa)的诊断、治疗及预后情况。方法:分析11例50岁以下PCa患者的发病年龄、主要症状、前列腺特异性抗原(PSA),病理诊断、治疗方法、预后情况,并进行文献资料复习。结果:11例患者平均年龄45.6岁,平均PSA 22.3μg/L,平均Gleason评分为7.7分。资料完整患者9例,1例骨扫描提示全身多发骨转移,8例未见转移灶;临床分期T1期3例,T2期5例,T3期1例。随访9例,1例行内分泌治疗1.5年后去世,1例经尿道前列腺切除术(TURP)后偶发癌观察等待,7例行前列腺癌根治术患者平均随访4年,3例生化复发,其余4例无生化和临床复发。结论:应提高对50岁以下PCa的警惕性,PSA检查有助于早期诊断,前列腺癌根治术对无远处转移的患者具有良好的治疗效果。
Objective: To investigate the diagnosis, treatment and prognosis of prostate cancer (PCa) under 50 years of age. Methods: The age of onset, major symptoms, prostate specific antigen (PSA), pathological diagnosis, treatment and prognosis of 11 cases of PCa under 50 years old were analyzed and literature review was conducted. Results: The average age of 11 patients was 45.6 years with a mean PSA of 22.3 μg / L and an average Gleason score of 7.7. There were 9 patients with complete data and 1 bone scintigraphy with multiple bone metastases. There were no metastases in 8 cases. There were 3 cases in T1 stage, 5 cases in T2 stage and 1 in T3 stage. Nine patients were followed up. One patient underwent endocrine therapy died after 1.5 years. One patient underwent esophageal cancer after TURP. The average follow-up of 7 patients with radical prostatectomy was 4 years. Three patients had biochemical recurrence and the remaining 4 Cases without biochemical and clinical relapse. CONCLUSIONS: Vigilance should be increased for PCa under 50 years of age, with PSA testing being useful for early diagnosis and radical prostatectomy for patients with distant metastases.