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用乙咪酯长期镇静或进行麻醉诱导者的肾上腺皮质功能受到抑制。作者研究乙咪酯在非麻醉诱导量是否比麻醉诱导量更容易引起肾上腺皮质功能和性腺功能的抑制。3例受试者接受负荷剂量乙咪酯(0.03mg/kg),然后连续四小时,给与0.3mg/kg/h的维持量。精神测定试验表明,此种给药法不会使受试者的失眠或大脑功能受影响。给药前30分和2分各采集一次血样测定类固醇激素和血浆中ACTH浓度。给药期间则每小时取血样一次。给药后4小时和随后4小时仍每小时取血样一次。用放射免
Cetuximab long-term sedation or anesthesia induced by the adrenal cortex function was inhibited. The authors investigated whether propidium iodide is more likely to cause inhibition of adrenocortical and gonadal functions than non-narcotics-induced amounts of non-narcotics. Three subjects received the loading dose of bimodipine (0.03 mg / kg), followed by a maintenance dose of 0.3 mg / kg / h for four consecutive hours. Psychometric tests show that this method of administration does not affect subjects’ insomnia or brain function. Blood samples were collected at 30 and 2 minutes prior to dosing to determine steroid hormones and plasma ACTH concentrations. Blood samples were taken every hour during the dosing period. Four hours after the administration and four hours thereafter, the blood samples were still taken hourly. With radio-free