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目的 探讨12 5I粒永久植入及氯化锶 [89SrCl2 ]静脉注射治疗雄激素非依赖型伴骨转移前列腺癌的疗效 .方法 在直肠B超引导下 ,经会阴穿刺将12 5I粒子植入到前列腺组织中进行组织间放疗 ,静脉注射89SrCl2 111～14 8MBq/次 ,治疗前列腺癌伴骨转移患者 11例 .结果 随访 3～ 12个月 ,8例前列腺体积缩小 ,PSA 3例降至正常、5例不同程度下降、2例无变化 ,1例上升 ;骨痛完全缓解 3例 ,部分缓解 5例 ,2～ 6个月后X线片及骨扫描显示病灶部分消失、变淡 5例 ;治疗一周后 4例出现白细胞及血小板计数下降 ,但 4～ 5周后渐恢复治疗前水平 ;术后未出现严重放射并发症 .结论 12 5I粒永久植入及89SrCl2 治疗骨转移前列腺癌是比较有效而且安全
Objective To investigate the effect of permanent 125 I seed implantation and intravenous injection of strontium chloride [89SrCl2] in the treatment of androgen-independent prostate cancer with prostatectomy.Methods 125I seeds were implanted into the prostate via perineal puncture under the guidance of rectum B- Tissue radiotherapy and intravenous injection of 89SrCl2 111 ~ 14 8MBq / times, the treatment of prostate cancer with bone metastases in 11 cases.Results Follow-up 3 to 12 months, 8 cases of prostate volume reduced, PSA decreased to normal in 3 cases, 5 cases There was no change in 2 cases and 1 case increased. Three cases were completely relieved of bone pain and 5 cases were partly relieved. X-ray and bone scan showed disappearance of the lesion partially and disappeared after 2 ~ 6 months in 5 cases. After one week of treatment In 4 cases, leukocyte count and platelet count decreased, but gradually recovered to the level before treatment after 4 ~ 5 weeks.No serious radiation complications occurred after operation.Conclusion Permanent 125 I seed implantation and 89SrCl2 treatment of bone metastases of prostate cancer are more effective and safe