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目的:观察右美托咪啶用于预防经尿道前列腺电切术(TURP)中寒战反应的效果。方法:60例ASAⅠ~Ⅱ级择期在腰麻硬膜外联合麻醉下行TURP的患者,随机均分为D组(右美托咪啶组)和C组(对照组)。D组和C组于麻醉后5min分别静脉泵注右美托咪啶0.5μg.kg-1和生理盐水(泵注时间为10 min)。观察术中两组患者寒战发生情况及镇静情况。结果:D组有3例患者(10%)发生寒战,C组有14例患者(46.7%)发生寒战(P<0.05);寒战程度D组显著低于C组(P<0.05),术中D组所有患者和C组3例患者的Ramsay评分为3~4分(P<0.05)。结论:静脉泵注0.5μg.kg-1右美托咪啶能安全有效降低TURP术中患者寒战的发生率。
Objective: To observe the effect of dexmedetomidine in preventing cholera reaction in transurethral resection of prostate (TURP). Methods: Sixty patients with ASA Ⅰ ~ Ⅱ elective TURP under epidural anesthesia were divided randomly into group D (dexmedetomidine group) and group C (control group). Group D and C were given intravenous drip of dexmedetomidine 0.5μg.kg-1 and saline (pump-infusion time 10min) 5 min after anesthesia. To observe the occurrence and sedation of cholera in both groups during surgery. Results: Chills occurred in 3 patients (10%) in Group D, chills occurred in 14 patients (46.7%) in Group C (P <0.05), and chills in Group D were significantly lower than those in Group C (P <0.05) The Ramsay scores of all patients in group D and those in group C were 3 to 4 (P <0.05). Conclusion: Intravenous injection of dexmedetomidine 0.5μg.kg-1 can reduce the incidence of cholera in patients undergoing TURP safely and effectively.