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目的探讨中国成都地区汉族人群单核苷酸多态性位点rs1333049与多囊卵巢综合征的相关性。方法抽选122例多囊卵巢综合征患者(观察组)和141例健康对照者(对照组)作为研究对象,采用Taq Man单核苷酸多态性基因分型技术对所有研究对象基因型进行分析,探讨成都地区汉族人群rs1333049多态性与多囊卵巢综合征相关性。结果观察组患者中临床表现和相关生化指标在不同基因型间无统计学差异,观察组和对照组基因型分布和等位基因分布频率无统计学差异。结论成都地区汉族人群rs1333049多态性与多囊卵巢综合征不具有相关性。
Objective To investigate the association of SNP rs1333049 with polycystic ovary syndrome in Han nationality in Chengdu, China. Methods A total of 122 patients with PCOS (observation group) and 141 healthy controls (control group) were enrolled in this study. All subjects were genotyped by Taq Man SNP genotyping To investigate the association between rs1333049 polymorphism and polycystic ovary syndrome in Chengdu Han population. Results There was no significant difference in clinical manifestations and related biochemical indexes among different genotypes in observation group. There was no significant difference in genotype distribution and allele frequency among observation group and control group. Conclusion There is no correlation between rs1333049 polymorphism and polycystic ovary syndrome in Chengdu Han population.