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骨质疏松症及其骨折是骨髓移植(BMT)受者的重要病变之一。为确定慢性GVHD接受异基因BMT受者骨密度降低状况及骨代谢相关参数与骨质疏松症发生的关系,作者进行了研究。 9例异基因BMT后3个月发生慢性GVHD患者,男6例,女3例,年龄31～47岁。采用强的松及CsA治疗。除进行腕骨单光子吸光测定(SPA)及腰椎双光子吸光测定(DPA)或双能X线吸光测定(DEXA)外,同时进行①24小时尿羟脯氨酸、镁、钙、钾、钠及尿肌酐;②血清肌酐、镁、白蛋白、胆红素、钙、磷;③空腹血清锌、25(OH)D及1,25(OH)_2D、中分子甲状旁腺素(PTH)及游离钙。BMT后1年(研究末期)行上述指标对比,并进
Osteoporosis and its fractures are one of the most important lesions in recipients of bone marrow transplantation (BMT). To determine the status of bone mineral density loss in allogeneic BMT recipients with chronic GVHD and the relationship between bone metabolism and osteoporosis, the authors studied. Nine cases of chronic GVHD occurred in 3 months after allogeneic BMT. There were 6 males and 3 females, ranging in age from 31 to 47 years. Treatment with prednisone and CsA. In addition to carpal single photon absorptiometry (SPA) and lumbar two-photon absorptiometry (DPA) or dual-energy X-ray absorptiometry (DEXA), at the same time ① 24 hours urine hydroxyproline, magnesium, calcium, potassium, sodium and urine Creatinine; ② serum creatinine, magnesium, albumin, bilirubin, calcium and phosphorus; ③ fasting serum zinc, 25 (OH) D and 1,25 (OH) _2D, middle molecular parathyroid hormone (PTH) and free calcium . One year after BMT (study period), the above indexes were compared and progressed