口服环孢菌素对难治性炎性肠道疾病有效,但该药的肾毒性限制了其应用。本文对环孢菌素灌肠治疗炎性直肠、结肠疾病进行了研究。选择8例经常规治疗无效的溃疡性结肠炎及慢性活动性直肠炎作为观察对象。本组病例病程2～22年,平均6年。治疗方法:环孢菌素5毫升(250毫克)、山梨醇5.5克和羧甲基纤维素钠600毫克,溶于 Oral cyclosporin is effective in refractory inflammatory bowel disease but its nephrotoxicity limits its use. In this paper, cyclosporin enema treatment of inflammatory rectal, colon disease were studied. Eight patients with ulcerative colitis and chronic active proctitis, which were ineffectively treated by conventional therapy, were selected as the observation subjects. The duration of this group of patients 2 to 22 years, an average of 6 years. Treatment: Cyclosporine 5 ml (250 mg), sorbitol 5.5 g and sodium carboxymethyl cellulose 600 mg, dissolved in