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目的探讨急性胰腺炎(AP)患者并发肝脏损害的临床特点以探讨其发病机制。方法对我院2003年1月至2005年8月收治的90例急性胰腺炎病例资料进行回顾性分析。结果急性胰腺炎患者中有60例发生肝损害,占66.7%,其中轻症胰腺炎(MAP)41例,占57.7%,重症(SAP)19例,占100%,MAP肝功能损害较SAP轻,差异有统计学意义(P<0.05);重症者肝功能损害程度较轻症者重,肝功能恢复时间延长。结论急性胰腺炎大多伴有肝损害,其损害程度与胰腺炎病情严重程度有关。病因、各种破坏因子、各种氧自由基、炎性递质的参与、内毒素作用等因素,在AP伴肝损害的发病机制中占有重要地位。
Objective To investigate the clinical features of liver injury in patients with acute pancreatitis (AP) to explore its pathogenesis. Methods The data of 90 cases of acute pancreatitis admitted to our hospital from January 2003 to August 2005 were analyzed retrospectively. Results There were 60 cases of acute pancreatitis with liver damage, accounting for 66.7%. Among them, 41 cases were mild pancreatitis (MAP), accounting for 57.7%, 19 cases were severe (SAP), accounting for 100% , The difference was statistically significant (P <0.05); severe cases of liver damage less severe weight, liver function recovery time. Conclusion Most of acute pancreatitis accompanied by liver damage, the extent of the damage and the severity of pancreatitis. Etiology, a variety of destructive factors, a variety of oxygen free radicals, the involvement of inflammatory neurotransmitters, endotoxin and other factors play an important role in the pathogenesis of AP with liver damage.