心得安是临床使用最早而指征广泛的非选择性亲脂性β—受体阻滞剂,它不仅对心血管疾病如高血压,心律失常,心绞痛,心肌梗塞治疗有效,亦广泛应用于非心血管疾病如β—受体机能亢进综合征,甲亢,门脉高压等神经精神,内分泌及其它脏器系统疾患。临床上由于突然停止使用心得安而使原有症状再现或恶化,国内外陆续报道,称之为停阻滞刻反应或心得安停药效应。现将临床上遇到的三例突然 Adiponax is the earliest and most widely used non-selective lipophilic β-blocker in clinical practice. It is not only effective in the treatment of cardiovascular diseases such as hypertension, arrhythmia, angina, and myocardial infarction, but also widely used in non-cardiac Vascular diseases such as β-receptor hyperactivity syndrome, hyperthyroidism, portal hypertension and other neuropsychiatric disorders, endocrine and other organ diseases. Clinically because of the sudden stop using the peace of mind so that the original symptoms reproduce or worsen, one after another reported at home and abroad, called the stop blocking reaction or arrest the effect of withdrawal. Now clinically encountered in three cases suddenly