Whether the mixing of scalar meson exists or not is an interesting question. We consider the mixing of scalar meson and further study the nucleon-nucleon interaction in the chiral SU(3) quark model by solving the resonating group method equation. The results are analyzed and compared with no mixing, ideal mixing and general mixing. It seems that the nucleon-nucleon interaction and binding energy of deuteron can be reasonably described with the different mixing of scalar meson.