在妊娠初期母体脂肪储存较稳定,虽然在妊娠晚期母体要不断地供给胎儿葡萄糖、氨基酸和其他物质。这些变化无论人类和小白鼠均与其母体内分泌改变以及血脂明显增高有关。在妊娠六个月后,母体血浆游离脂肪酸(FFA)和甘油三酯含量均相当高。因为脂质不易通过胎盘,这些变化虽然主要为满足母体需要,但在间接上也促使其它物质进入胎儿体内。本文目的在于探讨引起母亲高脂血症的主要原因,并阐明此变化对胎儿的影响,介绍妊娠晚期母体-胎儿间脂质代谢相互作用的新的见解。母亲肪组织分解对胎儿营养的重要性妊娠晚期母亲脂肪分解增强,使母体FFA和甘油释放到血循环的量增多,并使其在血浆中的含量增高。肝脏为此两种脂肪分解产物的主要受体,表现在肝切除后,此两种物质在血浆中明显增高。脂肪酸在肝脏中被活化,或用于甘油脂合成中的脂化作用,或用于乙酰辅酶A的降解和经β-氧化途径的酮体合成,而甘油以其α-甘油-磷酸盐形式用于甘油酯甘油的 Maternal fat storage is stable during the first trimester of pregnancy, although maternal glucose, amino acids and other substances should be continuously supplied in the third trimester. These changes both in humans and mice are associated with changes in their maternal endocrine and blood lipid was significantly higher. After six months of pregnancy, maternal plasma free fatty acids (FFA) and triglyceride levels are quite high. Because lipids do not readily pass through the placenta, these changes, while primarily meeting the maternal needs, also indirectly cause other substances to enter the fetus. The purpose of this paper is to explore the main causes of maternal hyperlipidemia and to elucidate the effects of this change on the fetus and to introduce new insights into the maternal-fetal lipid metabolism interactions in the third trimester of pregnancy. The Importance of Maternal Tissue Decomposition for Fetal Nutrition An enhanced maternal lipolytic profile in the third trimester increases the amount of maternal FFA and glycerol released into the bloodstream and increases their levels in the plasma. The liver is the main receptor of the two lipolysis products, manifested in the liver resection, the two substances was significantly increased in plasma. Fatty acids are activated in the liver, either for lipidation in glycerolipid synthesis, or for the degradation of acetyl-CoA and ketone bodies via the [beta] -oxidation pathway, whereas glycerol is used in its [alpha] -glycerophosphate form Glyceride glycerol