目的　了解儿童感染性心内膜炎 (IE)的病因、治愈率和死亡率。方法　对 1972年～ 1996年住院 5 3例IE的病因诊断、治疗、死因进行分析。结果　先心病居首位 43例 ( 81.13 % ) ,其次为风心病 ;2 4/ 49例血培养阳性 ( 46 .15 % ) ,9例培养出金葡菌 ;治愈 2 7例 ,治愈率 5 0 .95 % ,其中 1972年～ 1982年治愈 4/ 19例 ,治愈率 2 1.0 5 % ,1982年～ 1996年治愈 2 3/ 34例 ,治愈率6 7.6 4% ;死亡 12例 ,8例死于脑栓塞 ,4例死于心力衰竭。结论　早期诊断、及时足量应用杀菌性强的抗生素 ,二种以上联合应用 ,治愈率高 Objective To understand the etiology, cure rate and mortality of children with infective endocarditis (IE). Methods Etiological diagnosis, treatment and cause of death of 53 cases of hospitalized in 1972 ~ 1996 were analyzed. Results The first case of congenital heart disease was 43 cases (81.13%), followed by rheumatic heart disease; 24/49 cases of blood culture positive (46.15%), 9 cases of Staphylococcus aureus; cured 27 cases, the cure rate 50 .95%, of which 4/19 cases were cured from 1972 to 1982, the cure rate was 2 1.05%. From 1982 to 1996, 23 cases were cured and the cure rate was 7.664%. There were 12 deaths and 8 died of Cerebral embolism, 4 patients died of heart failure. Conclusion Early diagnosis, timely and adequate use of bactericidal antibiotics, more than two kinds of joint application, the cure rate