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目的探讨血中胃泌素(GAS)、胃酸分泌变化在新生儿窒息后发生胃肠功能障碍中的意义。方法对117例新生儿窒息引起胃肠功能障碍的59例患儿分别采用动态监测法测定分析其出生后1,3,7 d空腹静脉血GAS,胃液PH,并取同期本院收治的非窒息新生儿60例作为对照。结果①窒息后发生胃肠功能障碍患儿第1,3d血GAS显著低于无障碍组和对照组,其中尤以第1d为显著,有统计学意义(P<0.05);胃液pH值则第1d显著低于无障碍组和对照组,差异有统计学意义(P<0.05)。②重度窒息组第1、3 d血GAS明显高于轻度窒息组,胃液PH值低于轻度窒息组。结论窒息新生儿GAS和胃酸分泌异常可能与胃肠道功能紊乱有关,且窒息程度越严重,胃肠功能障碍发生率越高。
Objective To investigate the significance of blood gastrin (GAS) and gastric acid secretion in gastrointestinal dysfunction after neonatal asphyxia. Methods A total of 117 children with gastrointestinal dysfunction caused by asphyxia of newborns were enrolled in this study. The fasting venous blood GAS and gastric juice PH were analyzed by dynamic monitoring at 1, 3, 7 days after birth. The non-asphyxia 60 newborns as a control. Results ① The blood GAS in children with gastrointestinal dysfunction after asphyxia were significantly lower than those in the control group and those in the first and third day, especially in the first day (P <0.05) 1d was significantly lower than the accessibility group and the control group, the difference was statistically significant (P <0.05). ② Serum GAS in severe asphyxia group was significantly higher than that in mild asphyxia group at the first and third day, PH value in gastric juice was lower than mild asphyxia group. Conclusion Asphyxia neonatal GAS and abnormal gastric acid secretion may be related to gastrointestinal disorders, and the more serious the degree of asphyxia, the higher the incidence of gastrointestinal dysfunction.