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以对氯氯苄与盐酸吡啶缩合法制备 2 -对氯苄基吡啶 .考察了用料配比、催化剂用量、反应时间、反应温度、保温时间等因素对产品收率的影响 ,确定了较佳工艺条件为 :n(对氯氯苄 )∶n(盐酸吡啶 )=1 .6∶1 .0 ,m(氯化铜 )∶m(盐酸吡啶 ) =1 5∶1 0 0 ,反应温度 1 6 0～ 1 70℃ ,反应时间 2h,保温时间 7h ,无水吡啶加入量 1 0ml.在较佳反应条件下 ,2 -对氯苄基吡啶的收率可达 5 8.4 % ,并用气相色谱法程序升温分析该反应体系 ,效果良好
The synthesis of 2 - p - chlorobenzylpyridine by the condensation of p - chlorobenzyl chloride and pyridine hydrochloride was studied.The effects of the ratio of the raw materials, the amount of the catalyst, the reaction time, the reaction temperature and the holding time on the yield of the product were investigated, The process conditions are as follows: n (p-chlorobenzyl): n (pyridine hydrochloride) = 1. 6: 1 .0 m (cupric chloride): m (pyridine hydrochloride) = 1 5: 1 0 0, reaction temperature 16 0 ~ 1 70 ℃, reaction time 2h, holding time 7h, the amount of anhydrous pyridine added 10ml. Under the optimum reaction conditions, the yield of 2-p-chlorobenzyl pyridine can reach 5 8.4%, and by gas chromatography Analysis of the reaction temperature, the effect is good