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自从七十年代开始进行DNA甲基化的研究以来,已发现DNA甲基化程度与结构性异染质形成、X染色体失活以及病毒转染效率有关,而且大部分病毒和真核基因的甲基化程度与基因表达呈负相关。在肿瘤发生中,初步发现c-myc、c-ras、v-fes等癌基因的甲基化程度与基因表达也呈(?)相关。本文就DNA甲基化的形成、DNA甲基化的遗传及DNA甲基化与基因调控的关系做了介绍。
Since the study of DNA methylation began in the 1970s, it has been found that the degree of DNA methylation is related to the formation of structural heterochromatic substances, X chromosome inactivation, and virus transfection efficiency, and that most viruses and eukaryotic genes are The degree of basification was negatively correlated with gene expression. In tumorigenesis, the degree of methylation of oncogenes such as c-myc, c-ras, and v-fes was preliminarily found to correlate with gene expression (?). This article describes the formation of DNA methylation, the genetics of DNA methylation, and the relationship between DNA methylation and gene regulation.