论文部分内容阅读
我院1983年至1985年7月,共测定血清样品1609例。其中正常人普查1080例,原发性肝癌157例,转移性肝癌6例,急性黄疸性肝炎7例,乙型肝炎11例,慢性肝炎117例,肝硬化81例,肝肿大50例,胆囊癌1例,胰头癌2例,卵巢癌1例,肝包虫14例,肝脓疡5例。 84年下半年,对湟中、大通县和西宁地区部分单位职工及对门诊部分体检老干部、中、老年知识分子做了血清AFP测定,男性923例(85.5％),女性15.7例(14.5％),其中除有慢性肝病史的32例(3％),血清AFP在25～200ng/ml低水平升高外,其余均在25ng/ml以下。本文157例原发性肝细胞癌,血清AFP阳性检出率89.8％。我省地处高原,地区辽阔,原发性肝细胞癌血清AFP阳性检出率与国内报导无明显差异。统计资料基本符合某些消化系统肿瘤转移和无肝转移的恶性神瘤及非恶性肝脏疾患如肝炎,肝硬化等也可出现血清AFP低,中水平升高的论述,并见41例肝包虫,3例(7.3％)AFP低水平升高。 157例原发性肝癌,16例(10.2％)AFP<25ng/ml,其中55岁以上5例(31.3％),小于55岁11例(68.7％),不能明显反映肝癌发病年龄与AFP阳性率的关系。甲胎蛋白(AFP)是胎儿时期出现的一种血清蛋白,主要由胚胎的肝细胞和卵黄囊组产生的,出生后不久即逐渐降至成人水平(<25ng/ml)。而肝癌的癌细胞也可合成此类蛋白并分泌到血液中。检测血清中甲胎蛋白(AFP),已经肯定了诊断原发性肝癌的价值。本文就我院三年检测AFP诊断原发性肝癌及其临床应用价值,作一总结和讨论。
In our hospital from 1983 to July 1985, a total of 1609 serum samples were tested. Among them, there were 1080 normal cases, 157 cases of primary liver cancer, 6 cases of metastatic liver cancer, 7 cases of acute icteric hepatitis, 11 cases of hepatitis B, 117 cases of chronic hepatitis, 81 cases of cirrhosis, and 50 cases of hepatomegaly. There were 1 case of cancer, 2 cases of pancreatic head cancer, 1 case of ovarian cancer, 14 cases of liver hydatid, and 5 cases of liver abscess. In the second half of 84 years, serum AFP was measured in some units of employees in Suizhong, Datong, and Xining districts, as well as in senior health officials of middle-aged and senior citizens. Among them, 923 cases (85.5%) were males and 15.7 cases (14.5%) were females. In addition to 32 cases (3%) with a history of chronic liver disease, serum AFP increased at low levels of 25 to 200 ng/ml, and the rest were below 25 ng/ml. In this paper, 157 cases of primary hepatocellular carcinoma, serum AFP positive detection rate of 89.8%. Our province is located in a plateau with a vast area. The positive rate of serum AFP in primary hepatocellular carcinoma is not significantly different from domestic reports. The statistical data are basically consistent with the malignant tumors of some digestive system tumor metastasis and non-liver metastasis and non-malignant liver diseases such as hepatitis, liver cirrhosis, etc. There may also be a discussion about the low and intermediate levels of serum AFP, and see 41 cases of liver worms. In 3 cases (7.3%), the level of AFP increased. In 157 patients with primary liver cancer, 16 patients (10.2%) had AFP<25ng/ml, of whom 55 patients were over 5 years old (31.3%), and less than 55 years old 11 patients (68.7%), which did not clearly reflect the onset age of liver cancer and the positive rate of AFP. Relationship. Alpha-fetoprotein (AFP) is a serum protein that occurs during the fetus and is mainly produced by embryonic hepatocytes and yolk sac groups and is gradually reduced to adult levels (<25 ng/ml) shortly after birth. Cancer cells of liver cancer can also synthesize such proteins and secrete them into the blood. Detection of serum alpha-fetoprotein (AFP) has confirmed the value of diagnosis of primary liver cancer. This article summarizes and discusses the three-year test of AFP in the diagnosis of primary liver cancer and its clinical application value.