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采用脑干诱发电位和耳蜗铺片技术,观察自由基清除剂——维生素E和辅酶Q_(10)对卡那霉素耳中毒的防治作用。其结果不支持关于自由基参与卡那霉素对听觉损害的假设,并就卡那霉素的耳毒作用和自由基清除剂对抗自由基的作用机理进行讨论。
Brainstem evoked potentials and cochlear implants were used to observe the preventive and therapeutic effects of free radical scavengers - vitamin E and coenzyme Q_ (10) on kanamycin ototoxicity. The results do not support the hypothesis that free radicals are involved in kanamycin on auditory impairment and discuss the mechanism of action of kanamycin on ototoxicity and free radical scavengers against free radicals.