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灭滴灵原是抗滴虫和阿米巴感染的药物。1962年偶用于治疗厌氧菌感染有效。近年来发现它对各种专性厌氧菌感染均有良效,但对需氧菌、兼性厌氧菌,及微需氧菌感染均无效,本品无毒,副作用少,用药后血和组织中包括各种体液如唾液、尿液、乳汁、羊水和脓液中均能迅速达到治疗浓度之上。能通过血脑屏障、可用口服、静滴、肛栓和局敷等多种方式给病。与临床常用其他抗菌药物无配伍禁忌。本文报告美国某医院临床广泛应用灭滴灵,在外科和妇产科防治厌氧菌感染的实验研究。
Metronidazole is an anti-trichomoniasis and amoeba drug. 1962 even used to treat anaerobic infections effective. In recent years, it was found to have a good effect on a variety of obligate anaerobic infections, but the aerobic, facultative anaerobe, and microaerophilic infections are ineffective, the product non-toxic, less side effects, blood after treatment And the organization including a variety of body fluids such as saliva, urine, milk, amniotic fluid and pus can quickly reach above the therapeutic concentration. Can be through the blood-brain barrier, available orally, intravenous infusion, anal suppository and Council and other ways to give disease. Contraindications incompatible with other commonly used antibacterial drugs in clinical practice. This article reports the clinical application of metronidazole widely used in a hospital in the United States to prevent anaerobic infections in surgery and obstetrics and gynecology.