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免疫脂质体(Immunoliposome,IL)和化学脂质体(Chemoliposome,CL)分别是抗体修饰的脂质体和含药的脂质体的简称。建议将含药的抗体修饰的人工脂质膜小胞简称为“化免脂质体(Chemoimmunoliposome,CIL)。最初将脂质体作为细胞膜模型,将抗原结合在脂质体上,研究能否使它成为抗体和杀伤性T细胞的靶,曾研究了将蛋白质抗原结合在脂质体表面上的方法,不久就发展到将抗体作为蛋白质制成抗体修饰的脂质体。另一方面在肿瘤免疫研究中,在膀胱癌细胞表面抗原和识别这种抗原的抗体研究中,采用骨髓瘤杂交技术,制得了对人膀胱癌的单
Immunoliposomes (ILs) and Chemoliposomes (CL) are short for antibody-modified liposomes and drug-containing liposomes, respectively. It is suggested that the artificial antibody-modified artificial lipid-membrane cells are referred to as “Chemoimmunoliposomes (CIL).” Initially, liposomes were used as a cell membrane model to bind the antigen to the liposomes, It has become the target of antibodies and killer T cells, and the method of binding protein antigens to the surface of liposomes has been studied, and soon it has been developed to use antibody as a protein to make antibody-modified liposomes. On the other hand, In the study, in the study of bladder cancer cell surface antigen and antibody recognizing this antigen, a single-stranded human bladder carcinoma