论文部分内容阅读
最近发现的调节糖酵解和糖异生的一种新物质—2,6二磷酸果糖(Fru-2,6-P_2)。这里就Fru-2,6-P_2的发现及其调节因子有关生物合成、分解及生理作用加以叙述。磷酸果糖激酶(PFK)在ATP+F6P(6-磷酸果糖)→F-1,6-P_2(1,6磷酸果糖)反应中起触酶作用,它的最大特点是在生理pH(7.4左右)下。受基质ATP 强烈抑制。Kagimoto、Furuya 和Uyeda 等让游离肝细胞与(胰)高血糖素作用,发现引起了PFK 磷酸化,也发现肝上清液中有能显著提高PFK 活性的低分子物质。Hers 和Pilkis 也报道了同样的PFK 活化因子。以后由三个小组进行了研究。首先确定了其化
Recently discovered is a new substance that regulates glycolysis and gluconeogenesis, fructose-2,6-diphosphate (Fru-2,6-P 2). Here are the findings of Fru-2,6-P_2 and its regulatory factors related to biosynthesis, decomposition and physiological effects are described. Phosphofructokinase (PFK) acts as an enzyme in the reaction of ATP + F6P (fructose 6-phosphate) → F-1,6-P 2 (fructose 1,6-phosphate) and its most prominent feature is its physiological pH (about 7.4) under. Strongly inhibited by matrix ATP. Kagimoto, Furuya, and Uyeda et al. (2) have shown that free hepatic cells interact with (glucagon), resulting in the phosphorylation of PFK and also found that there is a low molecular weight substance in the liver supernatant that significantly increases PFK activity. Hers and Pilkis also reported the same PFK activators. After three groups conducted a study. First determine its