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目的:研究血清锌、镉与前列腺癌(PCa)的关系,以探讨其在PCa诊断及防治中的价值。方法:选择PCa患者85例(PCa组)和健康体检者90例(对照组),抽取外周静脉血4ml,分离血清。采用原子吸收分光光度法测定血清中锌、镉含量。结果:PCa组血清锌为(63.92±19.10)μg/dl,显著低于对照组(103.61±32.43)μg/dl;而PCa组血清镉为(13.58±3.64)μg/dl,显著高于对照组(7.45±2.31)μg/dl(P<0.05)。PCa组血清锌与前列腺特异抗原(PSA)之间呈明显负相关(P<0.05),相关系数r=-0.74;血清镉与PSA之间呈明显正相关(P<0.05),相关系数r=0.65。结论:血清锌降低及血清镉升高可能与PCa的发生密切相关;检测血清锌、镉可能对PCa的早期诊断具有重要价值。
Objective: To study the relationship between serum zinc and cadmium and prostate cancer (PCa) and to explore its value in the diagnosis and prevention of PCa. Methods: Eighty-five PCa patients (PCa group) and 90 healthy volunteers (control group) were selected. Peripheral venous blood was drawn from 4ml and serum was separated. Determination of zinc and cadmium in serum by atomic absorption spectrophotometry. Results: Serum zinc in PCa group was (63.92 ± 19.10) μg / dl, which was significantly lower than that in control group (103.61 ± 32.43) μg / dl, while that in PCa group was (13.58 ± 3.64) μg / dl (7.45 ± 2.31) μg / dl (P <0.05). There was a significant negative correlation between serum zinc and prostate specific antigen (PSA) in PCa group (P <0.05), the correlation coefficient was -0.74; There was a positive correlation between serum cadmium and PSA (P <0.05) 0.65. Conclusion: Serum zinc and serum cadmium levels may be closely related to the occurrence of PCa. Detecting serum zinc and cadmium may be of great value in the early diagnosis of PCa.