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目的通过收集在广西生殖健康中心行体外受精-胚胎移植(IVF-ET)不孕症妇女子宫内膜和息肉组织做病理切片苏木素-伊红(HE.)染色和白血病抑制因子(LIF)免疫组化染色，观察LIF表达分布情况，为研究提高子宫内膜息肉(EP)不孕症患者妊娠率提供参考依据。方法在广西生殖健康中心收集30例确诊为EP不孕症并行IVF-ET患者的子宫内膜和息肉作研究组，另取30例同期在本中心以丈夫不育为主因行IVF-ET的非EP患者(接近正常)子宫内膜组织作正常对照组，同期再在广西医科大学一附院门诊收集30例非息肉、非不孕症的放取环诊刮患者子宫内膜组织作非IVF-ET对照组，分别进行病理切片H.E染色及LIF免疫组织化学染色。结果与对照组比较，研究组内膜主要为腺泡细胞胞浆强阳性表达而胞核不表达；腺腔分泌物及间质细胞胞浆也有一定阳性表达；研究组息肉散在小片状间质细胞胞浆强阳性表达，腺细胞基本无阳性表达。结论广西IVE-ET的EP不孕患者子宫内膜LIF在腺上皮胞浆强阳性表达而胞核不表达，息肉组织则间质部分表达而腺细胞不表达。“,”Objective To observe the expression and distribution of Leukemia Inhibitory Factor(LIF) Immunohistochemical staining in endometrium and Endometrial Polyp(EP) tissues who performed In Vitro Fertilization-Embryo Transfer (IVF-ET) in Guangxi Reproductive Health Center (GXRHC), so that to provide the reference for researching how to improve pregnancy rate in EP patients with infertility. Methods Col ected 30 patients who was diagnosed with EP infertility and planed perform IVF-ET in GXRHC as a research group, meanwhile, the other similar 30 cases were male factor (husband infertility) but no EP and close to the normal as a normal control group, 30 cases were col ected in the family planning outpatients of First Af iliated Hospital of Guangxi Medical University who put in or take out an intrauterine device (IUD) as a Nor IVF-ET control group. Al the endometrium or endometrial polyp tissues and specimens were obtained by hysteroscopic polypectomy or curet age surgery, and were done HE staining and LIF immunohistochemical staining, and then observed the expression of LIF. Results Compared with the control group, glandular cel s cytoplasm strong positive expression and the nuclei did not express; Lumens secretions and interstitial cel cytoplasm also to have a certain positive expression in a research group; a few smal region interstitial cel cytoplasm strong positive expression, but glandular cel almost no positive expression. Conclusion Glandular cel s cytoplasm higher positive expressed but the nuclei did not express with LIF in endometrium, and interstitial cel s partly positive expressed but glandular cel s did not express in Endometrial Polyps tissues of EP infertility women who perform IVE-ET in Guangxi.