急性淋巴细胞白血病(ALL)是一种常见的白血病,多见于儿童,它严重威胁着患者的生命。我国每年新诊断的ALL约为10,000人。近十年来,尽管缓介率有所提高,长期生存者亦日趋增多,但尚有20％患者虽用同样方法治疗而缺乏良好反应。因而攻克白血病成为当今世界的一大难题。越来越多的资料表明,染色体研究对探讨白血病的病因、诊断、分型、治疗和预后均提供科学依据。显带与高分辨染色体技术研究表明几乎所有ALL都存在克隆异常,并发现某些ALL的类 Acute lymphoblastic leukemia (ALL) is a common leukemia, more common in children, it is a serious threat to the patient’s life. The newly diagnosed ALL in our country is about 10,000 each year. In the past decade, despite the improvement of the remission rate and the increasing number of long-term survivors, 20% of patients still did not respond well to the same treatment. Thus to overcome leukemia has become a major problem in today’s world. More and more data show that chromosome research to explore the etiology, diagnosis, classification, treatment and prognosis of leukemia provide a scientific basis. Studies of banding and high-resolution chromosomes indicate that clonality is present in almost all ALL and that some ALL classes are found