Loess is widely distributed in China and the Loess Plateau is one of the major areas where strong earthquakes often take place. The seismic amplification effects were discovered in the Plateau during the Wenchuan Ms8.0 earthquake and some other strong events. Based on earth tremor observation, borehole exploration and site seismic response analysis, the site effects of topography of Loess Yuan on ground motion were investigated in details. The earth tremor investigation shows that predominant frequencies at the bottom sites of Loess Yuan are greater than those at the top obviously. The sites seismic response analysis shows that the Loess Yuan may amplify peak ground acceleration (PGA) by 1.44 2.0 times. Therefore, site effects of mountains and loess topography on ground motion should be taken account into in seismic design in loess regions. Loess is widely distributed in China and the Loess Plateau is one of the major areas where strong earthquakes often take place. The seismic amplification effects were discovered in the Plateau during the Wenchuan Ms8.0 earthquake and some other strong events. Based on earth tremor observation , borehole exploration and site seismic response analysis, the site effects of topography of Loess Yuan on ground motion were investigated in details. The earth tremor investigation showed that predominant frequencies at the bottom sites of Loess Yuan are greater than those at the top obviously. The sites seismic response analysis shows that the Loess Yuan may amplify peak ground acceleration (PGA) by 1.44 2.0 times. Therefore, site effects of mountains and loess topography on ground motion should be taken into in seismic design in loess regions.