肿瘤坏死因子相关的凋亡诱导配体(TRAIL)是近年来研究发现的肿瘤坏死因子超家族新成员,其广泛存在于人体组织中,参与机体免疫调节、免疫自稳和免疫监视。TRAIL受体表达于多种细胞表面。研究表明,TRAIL能够诱导肿瘤细胞凋亡,对正常细胞无明显不不良反应,TRAIL良好的抗肿瘤活性和安全性得到了广泛的认识。前列腺癌的发生发展受细胞凋亡机制调控,TRAIL能诱导前列腺癌细胞凋亡,在前列腺癌的治疗中具有广阔前景。 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a new member of the tumor necrosis factor superfamily discovered in recent years. It widely exists in human tissues and is involved in immune regulation, immune self-stabilization and immune surveillance. TRAIL receptors are expressed on a variety of cell surfaces. Studies have shown that, TRAIL can induce tumor cell apoptosis, no obvious adverse reactions to normal cells, TRAIL good anti-tumor activity and safety has been widely recognized. The development of prostate cancer is regulated by the apoptosis mechanism. TRAIL can induce the apoptosis of prostate cancer cells and has a bright future in the treatment of prostate cancer.