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观察了内毒素血症时血浆降钙素基因相关肽（ＣＧＲＰ）的变化及其与血流动力学改变的关系。结果表明，用辣椒素抑制ＣＧＲＰ再注射内毒素时，血浆ＣＧＲＰ的释放量仅为内毒素血症对照组的３９．１％，同时动物的平均动脉压（ＭＡＰ）、中心静脉压（ＣＶＰ）和总末梢阻力（ＴＰＲ）的降低幅度明显减少（分别为８７．５０±６．５７，３．８７±０．８８，３．０４±０．２７ｋＰａ）。当再次注射ＣＧＲＰ时，随着血浆ＣＧＲＰ含量的增加，ＭＡＰ、ＣＶＰ和ＴＰＲ又明显降低（分别６３．７５±５．１８，０．６０±１．５３，２．２８±０．２８ｋＰａ）。３组动物的血浆ＣＧＲＰ变化差值与ＭＡＰ的变化差值呈显著的负相关（分别为ｒ＝－０．８３９０，ｒ＝－０．８３６８，ｒ＝－０．９５６４；Ｐ＜０．０５，０．０５，０．０１），但与ＣＯ的变化差值无相关（分别ｒ＝０．３７５１，ｒ＝－０．２５７８，ｒ＝０．２２５８；Ｐ＞０．０５）。提示内毒素血症ＣＧＲＰ直接参与对血流动力学改变的作用，但并不直接影响心肌功能的改变。
The changes of plasma calcitonin gene related peptide (CGRP) in endotoxemia and its relationship with hemodynamic changes were observed. The results showed that the plasma CGRP release was only 39.1% of that in the endotoxemia control group, and mean arterial pressure (MAP), central venous pressure (CVP) and The reduction in total distal resistance (TPR) was significantly reduced (87.50 ± 6.57, 3.87 ± 0.88 and 3.04 ± 0.27 kPa, respectively). When CGRP was injected again, MAP, CVP and TPR decreased significantly with the increase of plasma CGRP (63.75 ± 5.18, 0.60 ± 1.53 and 2.28 ± 0.28 kPa, respectively). There was a significant negative correlation between the difference of plasma CGRP and the change of MAP in the three groups (r = -0.8390, r = -0.8368, r = -0.9564, P <0.05, 0.05,0.01), but not with the difference of CO (r = 0.3751, r = -0.2578, r = 0.2258, P> 0.05). It is suggested that endotoxemia CGRP is directly involved in the hemodynamic changes, but it does not directly affect the changes of cardiac function.