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目的:探讨血浆高敏C反应蛋白(hs-CRP)和半胱氨酸蛋白酶抑制剂-C(CystatinC)在心房颤动(房颤)发生中的意义以及CystatinC与hs-CRP的相关性。方法:选取房颤组103例,对照组112例,采用德国BN-ProSpec全自动速率散色比浊仪测定血浆hs-CRP和CystatinC的含量。结果:房颤组血浆hs-CRP和CystatinC的水平较对照组明显升高。房颤患者血浆CystatinC与hs-CRP之间存在强相关性,其相关系数r为0.488。结论:房颤患者血浆hs-CRP和CystatinC水平均明显升高,且CystatinC与hs-CRP存在强相关性,提示CystatinC可能为一个新的炎症因子,其升高在房颤的发生发展中可能起着重要的作用。
Objective: To investigate the significance of plasma high sensitive C-reactive protein (hs-CRP) and Cystatin C in the development of atrial fibrillation (AF) and the correlation between Cystatin C and hs-CRP. Methods: 103 cases of AF group and 112 cases of control group were selected. Plasma hs-CRP and Cystatin C levels were measured by German BN-ProSpec automatic rate turbidimeter. Results: The levels of plasma hs-CRP and CystatinC in AF group were significantly higher than those in control group. There was a strong correlation between plasma Cystatin C and hs-CRP in patients with atrial fibrillation. The correlation coefficient r was 0.488. CONCLUSIONS: The levels of hs-CRP and Cystatin C in plasma of patients with AF are significantly increased, and there is a strong correlation between Cystatin C and hs-CRP, suggesting that Cystatin C may be a new inflammatory factor that may play an important role in the occurrence and development of atrial fibrillation Important role.