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目的 探讨吡哌酸锌对大鼠胃酸、胃蛋白酶活性、胃壁粘液分泌的影响。方法 Wistar大鼠5 0只 ,体重 2 2 2± 11g ,随机分成 5组。各组分别灌胃 0 .5 %羧甲基纤维素钠、5 %西米替丁和 3个剂量组的吡哌酸锌 ,每天 1次 ,连续 6d后 ,结扎幽门 ,手术后 5h处死大鼠 ,取出胃液和胃 ,测定大鼠胃酸、胃蛋白酶活性和胃壁粘液的分泌。结果 吡哌酸锌能降低胃液量、减少胃总酸排出量 (P <0 .0 1)与抑制胃蛋白酶活性 ,也能显著增加胃壁粘液的分泌 (P <0 .0 0 1)。结论 吡哌酸锌能使胃粘膜损伤因素减弱 ,保护因素增强。
Objective To investigate the effects of zinc piperazinate on gastric acid, pepsin activity and gastric mucus secretion in rats. Methods Fifty Wistar rats weighing 2212 ± 11g were randomly divided into five groups. The rats in each group were intragastrically given 0.5% sodium carboxymethylcellulose, 5% cimetidine and 3 doses of zinc piperazepate once daily for 6 days, followed by ligation of the pylorus. Rats were sacrificed 5 hours after the operation , Gastric juice and stomach were removed, gastric acidity, pepsin activity and gastric mucus secretion were measured. Results ZnPF could decrease gastric juice volume, decrease total gastric acid output (P <0.01) and inhibit pepsin activity, but also significantly increase gastric mucus secretion (P <0.01). Conclusion ZnPF can weaken the gastric mucosal injury and enhance the protective factors.