Nanographenes (NGs) are exceptionally hydrophobic.They are insoluble in water,preventing the exploration and utilization of their photophysical properties under aqueous conditions.This work discloses an atomically precise water-soluble synthetic NG 1,featuring a 2 nm sp2 carbon skeleton appended with 12 branched triethylene glycol chains.It synergistically combines low critical solution temperature (LCST) behavior and a photothermal effect to create the first thermo-and photo-responsive atomically precise NG functioning in an aqueous solution.The LCST behavior can be attributed to a delicate balance of hydrophobic-hydrophilic interactions,providing a sensitive thermal response to changes over a temperature range of physiological interest (close to 37 ℃).Moreover,1 has considerable photothermal conversion capability,with irradiation of 1 in water by red or near infrared light increasing the solutions temperature to above the clouding point within seconds,leading to a reversible clear-to-turbid transition over many cycles without evident fatigue.