巨噬细胞在免疫和免疫正、负调节中占有极重要的地位,其作用机制也成为人们极感兴趣的问题。它作为一种分泌细胞,象淋巴细胞一样,能合成和分泌多种可溶性生物活性因子,如影响淋巴细胞活性的T、B淋巴细胞活化因子、DNA合成抑制因子、组织胺释放因子、生长促进因子及干扰素等。这些因子通过直接影响靶细胞的活性,从而调节机体免疫反应。本文仅就各种巨噬细胞因子的特性及作用等做一综述,以助于对其作用机制的了解。 一、影响T淋巴细胞活性的因子 1.T淋巴细胞活化因子 是一种蛋白质,分子量为70,000,不具有导致有丝分裂原特 Macrophages play a very important role in both positive and negative regulation of immunity and immunity, and their mechanism of action has also become a topic of great interest. As a secreting cell, like lymphocytes, it can synthesize and secrete a variety of soluble bioactive factors, such as T, B lymphocyte activating factor, DNA synthesis inhibiting factor, histamine releasing factor, growth promoting factor that affect lymphocyte activity And interferon. These factors regulate the body’s immune response by directly affecting the activity of target cells. This article only on the characteristics of various macrophage cytokines and so do a review, to help understand the mechanism of action. First, the impact of T lymphocyte activity factor 1. T lymphocyte activation factor is a protein with a molecular weight of 70,000, does not have the original cause of mitosis