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目的：探讨细胞减灭术及化疗对卵巢上皮性癌的治疗效果及影响因素。方法：回顾性分析１９８０年１月至１９９２年１２月在我院治疗且经细胞减灭术后肿瘤残留灶≤２ｃｍ的卵巢上皮性癌７６例的临床资料，其中，Ⅱ期２６例，Ⅲ期５０例；术后无残留灶者５２例，残留灶直径≤２ｃｍ者２４例。术后均采用ＣＡＰ方案（环磷酰胺、阿霉素、顺氯氨铂），ＡＰ方案（阿霉素、顺铂），ＣＥ方案（卡铂、表阿霉素）进行化疗。结果：总的５年生存率为３３．６％。其中，Ⅱ期为３４．９％，Ⅲ期为２９．５％（Ｐ＞０．１）。有残留灶与无残留灶者的５年生存率分别为１６．５％及３７．６％（Ｐ＜０．０５）。化疗疗程数＜８及≥８者的５年生存率分别为２０．０％及６０．１％（Ｐ＜０．００１）。结论：经细胞减灭术后，有无肿瘤残留灶和术后化疗的疗程数均与预后有关，其中化疗疗程数对生存期影响更大。
Objective: To investigate the therapeutic effect and influencing factors of cytoreductive surgery and chemotherapy on epithelial ovarian cancer. Methods: The clinical data of 76 cases of ovarian epithelial carcinoma with residual tumor less than 2cm after cytoreductive surgery in our hospital from January 1980 to December 1992 were retrospectively analyzed. Among them, 26 cases were in stage Ⅱ, 50 cases; no residual lesions in 52 cases, residual lesions diameter ≤ 2cm in 24 cases. All patients underwent chemotherapy with CAP regimen (cyclophosphamide, doxorubicin, cisplatin), AP regimen (doxorubicin, cisplatin) and CE regimen (carboplatin, epirubicin). Results: The overall 5-year survival rate was 33.6%. Among them, 34.9% in stage II and 29.5% in stage III (P> 0.1). The 5-year survival rates of patients with and without residual lesions were 16.5% and 37.6%, respectively (P <0.05). The 5-year survival rates of patients with chemotherapy <8 and ≥8 were 20.0% and 60.1%, respectively (P <0.001). Conclusion: After cytoreductive surgery, the number of tumor residual tumor and the number of postoperative chemotherapy are related to the prognosis, of which the number of chemotherapy cycles have a greater impact on survival.