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目的讨论《职业性急性二甲基甲酰胺中毒诊断标准》(GBZ 85-2002)中观察期的期限。方法收集烟台市职业病医院近期收治的3例急性二甲基甲酰胺中毒患者的临床资料,包括职业史、发病特点、演变过程、诊疗方案等。结果该3名患者均在接触二甲基甲酰胺3天后表现出恶心、呕吐、腹痛等消化系统症状,肝功能损害进行性加重。结论 GBZ 85-2002规定短期内接触较大剂量二甲基甲酰胺出现接触反应表现者,应观察24 h,作者认为24 h的观察期较短,至少应严密观察72h以上。
Objective To discuss the duration of the observation period in the Diagnostic Criteria for Occupational Acute Dimethylformamide Poisoning (GBZ 85-2002). Methods The clinical data of 3 cases of acute dimethylformamide poisoning admitted recently in Yantai Occupational Hospital were collected, including occupational history, incidence characteristics, evolutionary process, treatment plan and so on. Results All three patients showed nausea, vomiting, abdominal pain and other digestive symptoms 3 days after exposure to dimethylformamide, worsening of liver dysfunction. Conclusion GBZ 85-2002 provides a short-term exposure to larger doses of dimethylformamide exposure reaction performance should be observed 24 h, the author believes that the short observation period of 24 h, at least 72 h should be closely observed.