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目的观察低剂量阿司匹林对诱发排卵周期临床妊娠率及妊娠结局的影响。方法回顾分析296个促排卵周期,按是否加用阿司匹林分为两组,A组(服用阿司匹林组)和B组(不服用阿司匹林组)。分析比较两组促排卵的排卵率、妊娠率、排卵日子宫内膜厚度和形态以及两组患者的妊娠结局。结果两组患者排卵率无统计学差异。A组排卵日子宫内膜厚度和子宫内膜形态优于B组,A组妊娠率高于B组而流产率较B组降低。两组患者妊娠结局无统计学差异。结论低剂量阿司匹林与克罗米芬联合应用,有助于改善促排卵周期中子宫内膜容受性,从而提高促排卵周期的妊娠率,降低流产率。
Objective To observe the effect of low dose aspirin on clinical pregnancy rate and pregnancy outcome in induced ovulation cycle. Methods 296 cycles of ovulation induction were retrospectively analyzed. Patients were divided into two groups according to whether aspirin was added or not, group A (taking aspirin) and group B (not taking aspirin). The ovulation rate, pregnancy rate, endometrial thickness and morphology of ovulation day and the pregnancy outcome of two groups were analyzed and compared. Results There was no significant difference in ovulation rate between the two groups. In group A, endometrial thickness and endometrial morphology on ovulation day were superior to those in group B. The pregnancy rate in group A was higher than that in group B, and the abortion rate was lower than that in group B. There was no significant difference in pregnancy outcome between the two groups. Conclusions The combination of low-dose aspirin and clomiphene citrate helps to improve the endometrial receptivity in the ovulation-promoting cycle so as to improve the pregnancy rate and reduce the miscarriage rate in the ovulation-promoting cycle.