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目的分析男性原发性高尿酸血症的临床特征及血尿酸(UA)与代谢综合征(MS)各组分的关系。方法采用横断面研究方法,将1017例男性体检者按UA分为高尿酸血症组和正常尿酸组;按具有代谢综合征组分的数目不同分为5组(MS0,MS1,MS2,MS3及MS4),分析临床资料。结果高尿酸血症组肥胖、高血压、血脂紊乱患病率高于正常尿酸组,空腹血糖受损患病率两组间差别无统计学意义;MS0~4组间UA差别均有统计学意义;高尿酸血症组的体重指数(BMI)、舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、尿素氮(BUN)、肌酐(Cr)明显高于正常尿酸组,高密度脂蛋白胆固醇(HDL-C)明显低于正常尿酸组,收缩压(SBP)、空腹血糖(FPG)两组间差别无统计学意义(P>0.05);UA与年龄、BMI、TG、TC、Cr有线性回归关系。结论男性原发性高尿酸血症与代谢综合征关系密切。
Objective To analyze the clinical features of male primary hyperuricemia and the relationship between serum uric acid (UA) and various components of metabolic syndrome (MS). Methods A total of 1017 male subjects were divided into hyperuricemia group and normal uric acid group according to the cross-sectional study. According to the number of patients with metabolic syndrome, they were divided into five groups (MS0, MS1, MS2, MS3 and MS4), analysis of clinical data. Results The prevalence of obesity, hypertension and dyslipidemia in hyperuricemia group was higher than that in normal uric acid group, and there was no significant difference between the two groups in the prevalence of impaired fasting glucose. There was significant difference in UA among MS0 ~ 4 groups The body mass index (BMI), diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN) and creatinine (Cr) in hyperuricemia group were significantly higher than those in normal uric acid group HDL-C was significantly lower than that of normal uric acid group, SBP and FPG had no significant difference (P> 0.05); UA had no significant difference with age, BMI, TG, TC , Cr has a linear regression relationship. Conclusion Male patients with primary hyperuricemia and metabolic syndrome are closely related.