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目的:观察祛风湿方剂(方剂)对佐剂性关节炎(AA)的疗效。方法:以佐剂性关节炎大鼠作为类风湿性关节炎(RA)的病理模型,以强的松作为阳性对照药,研究中药祛风湿方剂对炎症及免疫反应的影响。结果:方剂抑制AA 大鼠足爪的肿胀;使血沉、白细胞计数及单核细胞百分率显著下降;淋巴细胞百分率上升;抑制性T淋巴细胞(CD+8 )百分率升高(P< 0.05)。方剂使小鼠的血清溶血素(HC50)显著降低(P< 0.05)。病理组织检查可见关节腔内炎细胞浸润及滑膜渗出减少。结论:方剂对大鼠AA 具有抗炎及免疫调节作用
OBJECTIVE: To observe the curative effect of Qufeng recipe (prescription) on adjuvant arthritis (AA). METHODS: Adjuvant arthritis rats were used as a pathological model of rheumatoid arthritis (RA) and prednisone was used as a positive control to study the effects of Chinese herbal medicine rheumatoid prescription on inflammation and immune response. RESULTS: Prescriptions inhibited the swelling of paws in AA rats; the percentage of ESR, white blood cell counts, and mononuclear cells decreased significantly; the percentage of lymphocytes increased; the percentage of suppressive T-lymphocytes (CD+8) increased (P<0.05). Prescriptions significantly reduced serum hemolysin (HC50) in mice (P<0.05). Pathological examination revealed that the inflammatory cells in the joint cavity were infiltrated and synovial leakage was reduced. Conclusion: Prescriptions have anti-inflammatory and immunomodulatory effects on rat AA