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生长抑素是脑内重要的神经递质，本研究旨在探讨脑缺血后生长抑素变化规律；实验采用４血管关闭的方法，制造ｗｉｓｔａｒ鼠全脑反复缺血再灌流长期生存动物模型，然后利用放免方法测定了额叶、颞叶、海马、丘脑、纹状体、脑干６个脑区缺血后生存不同时间的生长抑素含量。结果发现缺血即刻各脑区生长抑素含量和对照组相比差异不显著（Ｐ＞０．０５），缺血后１５天显著下降（Ｐ＜０．０１），３０天继续下降（Ｐ＜０．０１），６０天时变化方趋稳定，９０天和１８０天时和对照组比较仍有差异（Ｐ＜０．０１）。结果提示生长抑素下降与脑对缺血选择易损伤性有关，生长抑素参与了脑缺血病理生理全过程。
Somatostatin is an important brain neurotransmitter, the purpose of this study is to investigate the changes of somatostatin after cerebral ischemia; the experiment uses the method of 4-vessel occlusion to make long-term survival animal model of wistar rat global cerebral ischemia-reperfusion, The content of somatostatin in different brain regions of frontal lobe, temporal lobe, hippocampus, thalamus, striatum and brainstem was measured by radioimmunoassay. The results showed that the content of somatostatin in each brain area immediately after ischemia was not significantly different from that in control group (P> 0.05), significantly decreased on the 15th day after ischemia (P <0.01), and continued to decline on the 30th day (P < 0.01). The changes tended to be stable on the 60th day, but there were still differences between the control group and the 90th day and the 180th day (P <0.01). The results suggest that the decline of somatostatin is related to the vulnerability of the brain to ischemic selection, and somatostatin is involved in the whole process of pathophysiology of cerebral ischemia.