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灵芝(Ganoderma lucidum Karsten)的干燥子实体为重要的中药之一。长期以来作为治疗各种疾病的万应灵药而享有盛誉。近来报道了其水提物能抑制荷糖(即高血糖)大鼠的血糖水平,对正常小鼠有降糖作用,并分出三个多聚糖的活性成分-GanoderanA, B.C。本文通过对各项指标的测试探讨其主要活性成分B的降糖机制。将雄性小鼠空腹一昼夜后以四氧嘧啶32mg/kg jv,5d后致高血糖(血糖浓度200-
The dried fruit body of Ganoderma lucidum Karsten is one of the important herbs. It has long been renowned as a panacea for the treatment of various diseases. Recently, it has been reported that its aqueous extract can inhibit the blood sugar level of rats with heavy sugar (ie, hyperglycemia), have hypoglycemic effect on normal mice, and separate three active components of polysaccharides - GanoderanA, B.C. This article explores the hypoglycemic mechanism of its main active ingredient B by testing various indicators. The male mice were fasted overnight with alloxan 32 mg/kg jv and hyperglycemia after 5 days (glycemic concentration 200-