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目的 探讨缺氧对心血管活性物质的影响。 方法 利用低压舱对大鼠进行急性低气压重度缺氧实验 ,模拟升空至 75 0 0 m高度 ,停留 30 min,出舱后立即收集各种样本 ,用放射免疫法测定心血管活性物质含量 ,并分别与无缺氧的对照组大鼠比较。 结果 发现实验组血浆内皮素 (ET)、心钠素 (ANP)和右房肌 ANP明显升高 (P<0 .0 1和 P<0 .0 1) ;而血清内洋地黄素 (EDL S)、右房肌ET、肺组织 ANP和 ET均明显降低 (P<0 .0 0 1和 P<0 .0 1)。 结论 本实验说明急性缺氧能够引起大鼠心血管内分泌功能紊乱 ,导致多种心血管活性物质平衡失调 ,提示这些改变在缺氧性机体损害过程中可能起重要作用。
Objective To investigate the effect of hypoxia on cardiovascular active substances. Methods Acute hypobaric hypoxia was induced in rats by low pressure cabin. After the model was emptied to a height of 75 000 m and stayed for 30 min, various samples were collected immediately after exiting. The content of cardiovascular active substances was determined by radioimmunoassay, And compared with no hypoxia control rats. The results showed that the levels of plasma endothelin (ET), atrial natriuretic peptide (ANP) and right atrial muscle in the experimental group were significantly increased (P <0.01 and P <0.01), while the serum endoxin (EDL S ), Right atrium muscle ET, lung tissue ANP and ET were significantly decreased (P <0.01 and P <0.01). Conclusions This experiment shows that acute hypoxia can cause cardiovascular endocrine disorders in rats and lead to imbalance of a variety of cardiovascular active substances, suggesting that these changes may play an important role in hypoxic damage.