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目的:探讨异常孕产史夫妇与染色体核型异常的关系。方法:对977例异常孕产史夫妇进行外周血淋巴细胞培养及染色体核型分析。结果:染色体异常核型52例,染色体异常率为5.32%,其中,平衡异位26例,倒位13例,多态性变异11例,分别占染色体异常核型的50%、25%和21.2%。结论:染色体核型异常是导致异常孕产史的重要原因之一,对异常孕产史夫妇进行细胞遗传学检查十分必要。
Objective: To investigate the relationship between aberrant pregnancy history and maternal chromosomes and karyotypes. Methods: 977 cases of abnormal pregnancy history couples peripheral blood lymphocyte culture and karyotype analysis. Results: There were 52 karyotypes with chromosome abnormalities of 5.32%. Among them, 26 were ectopic, 13 were inverted and 11 were polymorphic, accounting for 50%, 25% and 21.2% of the karyotype, respectively %. Conclusion: Abnormal chromosomal karyotype is one of the important causes of abnormal pregnancy history. It is necessary to carry out cytogenetic examination for abnormal pregnancy history couples.