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目的：探讨慢性肾脏病1~5期患者高凝状态及氧化应激在肾功能进展中的作用，并探讨其机制。方法选取2013年1月~2015年1月泸州医学院附属医院肾脏内科收治住院的CKD患者，检测肾功能及相关凝血指标FIB、D-D及氧化应激指标MDA、GSH-Px。结果①与对照组相比，CKD5期患者凝血功能及氧化应激水平均随着肾小球滤过的下降而逐渐加重，而抗氧化作用减弱；②行单因素相关分析FIB、MDA、GSH-Px、TC在尿毒症组差异显著，其中FIB、MDA、TC与SCr呈正相关，GSH-Px与SCr呈负相关。结论慢性肾脏病1~5期患者高凝状态及氧化应激在肾功能进展中相互促进，相互影响，均参与并肾功能的恶化。“,”Objective To investigate the role of the hypercoagulable state and the oxidative stress in patients with chronic renal function in the progression of in 1 to 5 kidney disease, and to explore the mechanism. Methods From January 2013 to January 2015 Department of Nephrology, Affiliated Hospital of Luzhou Medical College CKD patients admitted to hospital, the detection of renal function and related coagulation FIB, DD and oxidative stress indicators MDA, GSH-Px. Results 1 compared with the control group, CKD5 patients with coagulation function and oxidative stress levels were decreased glomerular filtration with gradually increased, and decreased antioxidant; 2-line single-factor correlation analysis FIB, MDA. , GSH-Px, TC significant difference in uremia group, which FIB, MDA, TC was positively correlated with SCr, GSH-Px was negatively correlated with SCr. Conclusion The hypercoagulable state and oxidative stress of Chronic kidney disease patients in renal promote mutual progress and mutual influence, and are involved in the deterioration of renal function.