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目的研究随机尿IgG与尿肌酐比值(IgG/Cr)是否可以代替24 h尿蛋白定量(UPRO),用于子痫前期的诊断和病情监测。方法选取2013年5月-2015年5月在温州市中心医院收治的轻度子痫前期孕妇31例,重度子痫前期孕妇33例,正常孕妇25例,留取24 h尿液检测24 h尿蛋白,随机尿液检测尿白蛋白、尿IgG、尿肌酐;尿白蛋白/尿肌酐(A/Cr)、尿IgG/Cr和UPRO进行相关性分析。采取ROC曲线分析确定随机尿IgG/Cr相对应UPRO为0.3 g及5 g时的诊断界点。结果随机尿A/Cr、IgG/Cr同UPRO呈正相关(r值分别为0.646和0.872,P<0.01);随机尿IgG/Cr相对应UPRO为0.3 g及5 g时的诊断界点分别为15.6 mg/g、375.2 mg/g时,曲线下面积分别为0.963和0.917。结论随机尿IgG/Cr同24 h尿蛋白呈显著正相关,优于随机尿A/Cr,用于子痫前期诊断较24 h尿蛋白更为快捷和简便,有望成为子痫前期诊断指标。
Objective To investigate whether the ratio of random urine IgG to creatinine (IgG / Cr) can be used to replace UPRO 24 hours for the diagnosis and monitoring of preeclampsia. Methods 31 cases of mild preeclampsia, 33 cases of severe preeclampsia and 25 cases of normal pregnant women admitted to Wenzhou Central Hospital from May 2013 to May 2015 were enrolled. Urinary albumin, urinary IgG, urinary creatinine, urinary albumin / urinary creatinine (A / Cr), urinary IgG / Cr and UPRO were detected by random urine test. ROC curve analysis was used to determine the diagnostic cutoff point when the corresponding urinary IgG / Cr UPRO was 0.3 g and 5 g. Results There was a positive correlation between random urine A / Cr and IgG / Cr and UPRO (r = 0.646 and 0.872, respectively, P <0.01). The diagnostic cutoff points for random urine IgG / Cr with UPRO of 0.3 g and 5 g were 15.6 mg / g, 375.2 mg / g, the area under the curve was 0.963 and 0.917, respectively. Conclusions There is a significant positive correlation between random urine IgG / Cr and 24 h urinary protein, which is superior to random urine A / Cr. It is more convenient and quicker to diagnose preeclampsia than 24 h urinary protein. It is expected to be a diagnostic indicator of preeclampsia.