20世纪90年代初已发现,妇女孕前及孕早期增补叶酸可以降低胎儿神经管畸形的危险性。我国也在育龄妇女中推广叶酸增补剂,但某些地区的神经管畸形出生患病率并没有明显下降,原因尚不清楚。在“十五”国家科技攻关课题资助下,北京大学生育健康研究所对我国神经管畸形高发区的山西 It has been found in the early 1990s that the addition of folic acid to pre-pregnancy and early-pregnancy women can reduce the risk of fetal neural tube defects. China is also promoting folic acid supplements in women of childbearing age, but the prevalence of neural tube defects in some areas did not significantly decline, the reason is not clear. In the “Tenth Five-Year” national science and technology project funding, Peking University Institute of Reproductive Health of our country high incidence of neural tube defects in Shanxi