目的分析探讨环磷酰胺冲击治疗狼疮性肾炎的护理方法和效果。方法选择我院收治的80例环磷酰胺冲击治疗的狼疮性肾炎患者作为研究对象,收治时间在2013年2月至2014年3月期间,使用数字抽取法将这80例患者平均分成2组,实验组和对照组各40例,对照组给予常规护理,实验组给予全面护理,并在护理结束后,对比分析两组的并发症发生率和匹兹堡睡眠质量指数评分。结果实验组的并发症发生率为2.50%,低于对照组的15.00%(P<0.05);实验组的匹兹堡睡眠质量指数评分低于对照组(P<0.05)。结论环磷酰胺冲击治疗中给予狼疮性肾炎患者全面护理具有显著的作用。 Objective To investigate the nursing methods and effects of cyclophosphamide in the treatment of lupus nephritis. Methods Eighty patients with lupus nephritis treated with cyclophosphamide were selected as the study subjects. The duration of treatment was from February 2013 to March 2014, and the 80 patients were equally divided into two groups by digital extraction. The experimental group and the control group, 40 cases in each group. The control group was given routine nursing. The experimental group was given full care. After nursing, the incidence of complication and Pittsburgh sleep quality index were compared between the two groups. Results The incidence of complication in the experimental group was 2.50%, which was lower than that in the control group (15.00%, P <0.05). The Pittsburgh Sleep Quality Index score in the experimental group was lower than that in the control group (P <0.05). Conclusion Cyclophosphamide shock therapy in patients with lupus nephritis with a comprehensive nursing has a significant effect.