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目的分析微透析技术在药物代谢动力学研究中的应用现状,探索不同给药途径下,喹诺酮类药物在中枢内的药动学差异。方法检索国内外相关资料,归纳总结利用微透析技术研究外源性化学物质,特别是抗感染药物药动学的优点,分析喹诺酮类药物在中枢神经系统的应用及药动学研究现状。结果通过微透析取样,可获得异源物质的动力学数据,且不会引起实验动物明显的生理变化。喹诺酮类药物具有良好的血脑屏障穿透力和抗菌活性,适用于中枢神经系统敏感菌株感染的治疗。结论 利用微透析技术,比较口服和静脉给药途径下,喹诺酮类药物在中枢内的药动学差异,将会给临床给药途径的选择提供可靠的理论依据。
OBJECTIVE: To analyze the application of microdialysis in the study of pharmacokinetics and to explore the pharmacokinetics of quinolones in the central nervous system under different routes of administration. Methods Retrieve relevant data at home and abroad, summarize the application of microdialysis technology to study the advantages of exogenous chemical substances, especially anti-infective drugs pharmacokinetics, analysis of the application of quinolones in the central nervous system and pharmacokinetics. Results By microdialysis sampling, the kinetic data of the heterologous substances were obtained without significant physiological changes in the experimental animals. Quinolones have good blood-brain barrier penetration and antibacterial activity and are suitable for the treatment of infections of sensitive CNS strains. Conclusions Using microdialysis, comparing the pharmacokinetic differences of quinolones with those of oral and intravenous routes of administration will provide a reliable theoretical basis for the choice of clinical route of administration.