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家兔脑内接种Brown-Pearce癌,成瘤率达100％。从小脑、大脑和丘脑不同部位接种时,家兔的平均生存时间分别为12.4,11.2和10.8天。在接种Brown-Pearce癌后10天测量肿瘤大小,结果以丘脑肿瘤最大,平均面积为21.5mm~2,大脑和小脑肿瘤分别为11.8和5.2mm~2,三者差异非常显著。 每天静脉注射邻脂苯芥0.7mg/kg,共7～10天,可使小脑、大脑和丘脑接种Brown-Pearce癌家兔的生存时间显著延长,延长率分别为61～64％,33～38％和23～30％。提示邻脂苯芥经静脉注射能到达脑部肿瘤灶。疗效的差异可能与肿瘤在不同脑区生长的速率有关。 将肿瘤与邻脂苯芥在体外温浴后再接种到家兔脑内时,可使肿瘤成瘤率明显下降。
Rabbits inoculated Brown-Pearce cancer, tumor formation rate of 100%. When inoculated from different parts of cerebellum, brain and thalamus, the average survival time of rabbits were 12.4, 11.2 and 10.8 days, respectively. Tumor size was measured 10 days after inoculation of Brown-Pearce carcinoma. The results showed that the tumors in the thalamus were the largest, with an average area of 21.5 mm 2, with 11.8 and 5.2 mm 2 in brain and cerebellar tumors, respectively. The differences among the three groups were significant. Intraperitoneal injection of olanolipastat 0.7mg / kg, a total of 7 to 10 days, the cerebellum, cerebrum and thalamus inoculation Brown-Pearce cancer rabbits survival time significantly prolonged, respectively, 61 to 64%, 33 to 38 % And 23 to 30%. Tip olanipide intravenous injection can reach the brain tumor lesions. The difference in efficacy may be related to the rate of tumor growth in different brain regions. The tumors with ointment mustard in vitro warm bath and then inoculated into the brain of rabbits, can significantly reduce the rate of tumor formation.